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Article
August 1962

Use of Enzyme-Treated Heterografts as Segmental Arterial SubstitutesV. Influence of Processing Factors on Strength and Invasion by Host

Author Affiliations

NEW BRUNSWICK, N.J.
From the Vascular Surgical Service, Middlesex General Hospital, and the Johnson & Johnson Research Foundation, New Brunswick, N.J.

Arch Surg. 1962;85(2):192-197. doi:10.1001/archsurg.1962.01310020022006
Abstract

Enzyme-treated bovine arterial heterografts can function as segmental replacements in the abdominal aorta of the dog for long periods of time.1-4 The digestion of the vessel wall with a protease, ficin, and its subsequent formalin tanning, removes almost all of the smooth muscle and elastica, leaving a nonporous, strong collagen tube which does not leak blood through its substance.

In a group of 33 dogs, 12 of which were followed for approximately 5 years, the percentage of "successful" abdominal aortic grafts decreased from 73% of 2½ year survivors to 50% of those allowed to live the full duration of the study.4 All long-term grafts classed as "failures" were patent and unruptured at the time of final examination. Of 10 untreated controls with a 10% incidence of "success" by aortography at 2½ years (1 graft), 4 were kept for 5-year evaluation. Three were failures. One was "successful" grossly, but

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