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September 1962

Prolonged CardioplegiaThe Effects on Isolated Perfused Guinea Pig Hearts

Author Affiliations

From the Department of Surgery, The New York Hospital-Cornell Medical Center.

Arch Surg. 1962;85(3):483-491. doi:10.1001/archsurg.1962.01310030131021

Experimental and clinical cardioplegia has been achieved by various techniques including potassium citrate or chloride, acetylcholine, Sealy's mixture (K citrate plus MgSO4), anoxia, or hypothermia. Arrest has been maintained as long as 1 hour in the isolated guinea pig heart,1 and up to 58 minutes in patients as reported by Effler.2

Review of the literature in this field shows that little had been reported regarding prolonged periods of elective cardiac arrest. Since it is possible that the repair of complicated or multiple cardiac defects could require long periods of cardiac arrest, the present study was undertaken to evaluate the effects of extended periods of cardioplegia on the mechanical and electrical activity of the isolated guinea pig heart. Arrest was achieved using potassium citrate, Sealy's mixture, acetylcholine, A.C.D. solution, anoxia, or hypothermia.

Materials and Methods  Guinea pig hearts were removed and perfused as isolated preparations in the manner

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