November 1962

The Role of Serotonin in the "Dumping Syndrome"

Author Affiliations

Fellow, American Cancer Society 1961-1962 (Dr. Miller).; From the Harrison Department of Surgical Research and the Department of Surgery, Schools of Medicine, University of Pennsylvania.

Arch Surg. 1962;85(5):701-704. doi:10.1001/archsurg.1962.01310050003001

Since the original description of the "dumping syndrome" by Denechau,1 Hertz,2 and Mix,3 a great deal of clinical and experimental work has been devoted to the definition and etiology of this curious group of symptoms and signs. Individual reactions vary within broad limits, but, in general, may be divided into intestinal and vasomotor components. The "intestinal" portion of the syndrome may include hyperperistalsis, bloating, epigastric discomfort and fullness, mild cramps, borborygmi, nausea, and, occasionally, vomiting and diarrhea. The vasomotor component actually distinguishes "dumping" from other postgastrectomy syndromes and may be manifested by weakness, dizziness, pallor, tachycardia, sweating, palpitation, and a desire to lie down. In its more severe forms, the syndrome may be totally disabling for the patient.

Theories as to etiology have waxed and waned in acceptance in the past 2 decades. For example, the syndrome has been purported to be due to a reduction in

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