[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1963

Peripheral Vascular Tonus and ReactivityIndependent Variables

Author Affiliations

BROOKLYN
From the Vascular Surgical Service, Department of Surgery, State University of New York Down-state Medical Center, Brooklyn.

Arch Surg. 1963;86(1):13-21. doi:10.1001/archsurg.1963.01310070015003
Abstract

During our experiences with total body perfusion, using extracorporeal heart-lung bypass, we noted unexplained variations in the response of peripheral vascular resistance to standard test doses of vasomotor drugs. Further experimentation was performed using the mature dog and our heart-lung bypass apparatus designed previously for the study of the role of the pulse in maintenance of the systemic circulation.12 The arterial inflow to the animal was a continuous, pulseless, gravity perfusion at an essentially constant blood pressure. The present experiments are predicated on the following concepts: (1) Peripheral vascular tone is defined as the effective state of constriction or dilation of the peripheral vascular tree during a given steady state perfusion; it can be described by the ratio of the measured blood pressure and flow. (2) Peripheral vascular reactivity is defined as the change in the pressure-flow ratio following the introduction of some stimulus, such as a vasomotor drug.

First Page Preview View Large
First page PDF preview
First page PDF preview
×