Mediastinal tumors frequently have a neurogenic origin. This ranges from 19% to 39% when only intrinsic mediastinal lesions are considered but falls as lows as 4.8% when all tumors of any source are included.3,5,6,9,17,19,21,22 Table 1 records some of the details concerning 641 neurogenic tumors in 2,053 mediastinal tumors collected from the literature.
Peripheral neurogenic tumors arise from either ganglion or sheath cells. This report is concerned with nerve sheath tumors which are of 2 types. The neurilemmoma is encapsulated and has an organized architecture of cellular, fasciculated Antoni type A tissue containing Verocay bodies, with palisading or regimentation of nuclei and loose-textured, reticular, Antoni type B tissue containing microcysts. Cystic degeneration and necrosis are common. The neurofibroma is not encapsulated, has a poorly organized architecture, and contains neurites. It is frequently associated with von Recklinghausen's disease.
Although these tumors have a wide distribution, they rarely involve the vagus
ECKER RR, TIMMES JJ, MISCALL L. Neurogenic Tumors of the Intrathoracic Vagus NerveReport of 3 Cases and Review of the Literature. Arch Surg. 1963;86(2):222-229. doi:10.1001/archsurg.1963.01310080046011