The introduction of therapeutic preparations that produce a fibrinolytic state has created a need for a neutralizing agent or inhibitor that can be used in any emergency in the event of hemorrhage resulting from over-dosage of the drugs or hypersensitivity to them.
In 1953, De Vries6 demonstrated the activity of amino acids as inhibitors of fibrinolytic activity. In 1959 Okamoto and his co-workers15 published an account of their earlier discovery of ε-amino-caproic acid (EACA) as a potent inhibitor of fibrinolysis. They named the product Ipsilon.5,21 Sarker,19 Sjoerdsma,20 Ablondi,2 and Alkjaersig3 substantiated these findings.
The mechanism of inhibition of lysis by ε-amino-caproic acid has been shown to be one of preventing the activation of plasminogen rather than the neutralization of fibrinolytic activity of plasmin.1-3,10,8
The creation of a bleeding state in dogs by the use of plasmin or an activator, and its subsequent
BELKO JS, WARREN R, REGAN EE, SIMPSON RG. Induced Fibrinolytic Activity and HypofibrinogenemiaEffect of Epsilon-Amino-Caproic Acid. Arch Surg. 1963;86(3):396-401. doi:10.1001/archsurg.1963.01310090046009