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March 1963

Transplantation of Homologous and Heterologous TumorsStudies of Serotonin as a Conditioning Agent

Author Affiliations

From the Department of Surgery, Hahnemann Medical College.

Arch Surg. 1963;86(3):480-483. doi:10.1001/archsurg.1963.01310090130024

Introduction  Human tumors have been successfully transplanted into animals after conditioning the recipients with modalities such as irradiation and cortisone.1-3 Successful routine transplantation of human tumors from the operating room into animals might provide a means of determining sensitivity of these tumors to specific chemotherapeutic agents. At this time several problems exist in the transplantation of human tumors into small animals.1. The percentage of successful transplants is low.2. Animals conditioned with irradiation and cortisone are often in poor general condition by the time the tumors are growing.3. The animal develops an immunity to the transplanted human tumor requiring serial transplantation to preconditioned animals.This study was undertaken to determine whether other conditioning agents or modalities might be employed in the successful transplantation of human tumors. Serotonin* (5-hydroxytryptamine) was used in the conditioning of the host for transplantation of an established rat tumor and an established human

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