Homologous transplantation of vital organs, except under very specific conditions, still cannot be successfully carried out. Rejection of the donor tissue is presumed to be due to the development by the host of antibodies to the foreign antigen. Once this problem is solved, homologous transplantation of organs may become a clinical reality.
The development of a suitable technique for the homografting of lungs is thought to be worthwhile for two reasons: First, when organ transplantation does become a clinical reality, a suitable technique will have been established; second, a transplanted, and therefore, completely denervated lung makes an excellent preparation for physiologic study. The transplant can be compared grossly, histologically, and functionally with the contralateral intact lung. The functions of the lung, including ventilation and respiration, can be studied differentially. The lung can be studied radiographically. The intact tracheobronchial tree can be examined by bronchoscopy; and finally, since the lungs are
CHRISTIANSEN KH, SMITH DE, PINCH LW. Homologous Transplantation of Canine LungsTechnique with Contralateral Pulmonary Artery Ligation. Arch Surg. 1963;86(3):495-499. doi:10.1001/archsurg.1963.01310090145027