April 1963

Renal Transplantation in Identical Twins

Author Affiliations

Markle Scholar and Associate Professor of Surgery (Dr. Starzl); Instructor in Surgery (Dr. Brittain); Associate Professor of Surgery (Dr. Stonnington); Clinical Instructor in Surgery (Dr. Coppinger); Professor of Surgery (Dr. Waddell).; From the Departments of Medicine and Surgery, University of Colorado Medical Center, The Denver Veterans Administration Hospital, and the Denver Clinic.

Arch Surg. 1963;86(4):600-607. doi:10.1001/archsurg.1963.01310100084013

Since 1954, renal transplantation from one identical twin to another has been reported in 25 cases,1,6-9,12,15,18,22 of which 18 have been done by Murray and his associates15 in Boston. Inasmuch as such twins develop from the same fertilized ovum, their tissues are genetically identical and consequently mutually acceptable for homografting.5,13 The problems encountered with tissue transplantation under these circumstances are essentially technical and concern details of procurement, transfer, and revascularization of the kidney.

The present report is of a renal transplantation performed in March, 1962. The kidney was donated by a healthy 27-year-old man to his identical twin brother who suffered from terminal glomerulonephritis. In caring for these patients, some variations were evolved from the operative methods previously standardized by Murray, Merrill, and Harrison,13,18 involving not only the removal but the preservation and reimplantation of the kidney. In addition, a syndrome of postoperative microscopic hematuria occurred

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