Several functional disorders have been found in patients with acute pancreatitis. Bockus1 reported pathologic sulfobromophthalein (Bromsulphalein) retention associated with that disease in many patients. Howard2 also found abnormal liver function tests in several people afflicted by the same disease. Colp and Dreiling3 made similar observations.
Anatomical lesions have also been described by several writers. Fisher and McCloy4 reported hepatic lesions in 11 out of 14 cases of acute pancreatitis, consisting of biliary thrombi, sometimes associated with hepatic necrosis and hemorrhage. Howard2 and Edlund5 mention similar cases. Besides the liver, other viscera have been found to be affected during acute pancreatitis. Necrosis of the renal tubules, mainly at the lower nephron, was observed by Ferris, Lynn, Cain, and Baggenstoss.6 Vogel7 reported cerebral, cardiac, adrenal, and ovarian lesions found at autopsy of a case of acute pancreatitis.
We attempted to reproduce similar lesions experimentally
DOS REIS L. Visceral Lesions in Acute PancreatitisAn Experimental Study. Arch Surg. 1963;87(4):604-608. doi:10.1001/archsurg.1963.01310160066011