The Crosby intestinal biopsy capsule, which was developed at the Walter Reed Army Institute,1 makes it possible to obtain mucosal biopsies from virtually any part of the stomach or small intestine by passage of the capsule to the desired level of the gastrointestinal tract. The capsule can also be passed in a retrograde manner attached to a rectal tube2 to obtain biopsies of lesions of the descending colon.
The intestinal capsule biopsy tray utilized by our group is shown in Fig 1. The capsule must be firmly attached to the desired length of size 200 polyethylene tubing by utilizing heat to form a flange on the tubing. The spring and block with the sharpened knife are placed in proper position in the capsule and cocked in open position. The capsule cap and rubber diaphragm are then snapped tightly in place. The patient's gastrointestinal tract should be empty
NAGLER W, WATNE AL. The Intestinal Biopsy Capsule as a Diagnostic AidReport of a Case of Malabsorption Syndrome. Arch Surg. 1964;88(3):415-418. doi:10.1001/archsurg.1964.01310210089014