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June 1964

Hemodynamic Changes From Low Molecular Weight Dextran

Author Affiliations

Department of Surgical Physiology, Division of Basic Surgical Research, Walter Reed Army Institute of Research, Walter Reed Army Medical Center.

Arch Surg. 1964;88(6):999-1002. doi:10.1001/archsurg.1964.01310240095017

Hemodilution perfusion with 5% dextrose in water primes has been reported to have usefulness in total body bypass.1,2 The benefit of an extracorporeal circulation using this form of a dextrose prime has been attributed to its hemodilutory effects.1,2 This form of hemodilution is reported to beneficially reduce postoperative complications resulting in oliguria, or frank renal circulatory failure.1,2 Others have proposed3,4,5 that low molecular weight dextran (Rheomacrodex) also possessed similar beneficial properties when used as an extracorporeal circulation prime to replace blood. In addition to the hemodiluting properties, plasma volume expansion with low molecular weight dextran is reported to have additional viscosity altering effects which also improve blood flow.3,4,5

Under the preceding clinical situations, direct measurement of the actual cardiac and renal hemodynamic alterations have not been possible. We have therefore designed the present series of experiments in the dog to directly assess these alterations, as

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