The ill effects of excessive sympathetic stimulation in animals subjected to prolonged oligemic hypotension have been documented by many observers.1-6 These observations have led to the experimental and clinical use of ganglionic or adrenergic blocking agents to prevent harmful vasoconstriction in shock. Blocking agents have also been used to induce hypotension and to limit blood loss during major surgical procedures, suggesting that they could be useful in hemorrhagic shock to reduce uncontrolled bleeding as well.
On the other hand, observations in animals and man which have demonstrated a reduction in cardiac output or regional blood flows after the use of ganglionic blocking agents7-11 may arouse skepticism concerning the usefulness of these agents in hemorrhagic shock where the arterial pressure is already reduced and the cardiac output impaired.
In order to gain information concerning the adequacy of tissue perfusion with ganglionic blocking agents, studies have been made of the
HOPKINS RW, SIMEONE FA. Trimethaphan Camsylate in Hemorrhagic Shock. Arch Surg. 1964;89(2):365-372. doi:10.1001/archsurg.1964.01320020129019