Experiments performed recently in this laboratory4,6,7 have shown that many anticancer drugs are effective in preventing growth of cancer cells when they are used as irrigants one hour after implantation of cancer cells (Walker 256) into a subcutaneous wound. In experiments to be reported elsewhere5 we have noted that two of these compounds (sodium hypochlorite and sodium troclosene [ACL 60, sodium dichloroisocyanurate]) which act locally only, would actually increase the incidence of growth when used to irrigate the peritoneal cavity of rats one hour after implantation with Walker 256 cells. In experiments reported herein we have noted that at least one of these drugs used in our original experiments,7 namely A8103 (N,N′-bis-(3-bromopropionyl) piperazine) will decrease the incidence of growth of tumor cells when used as an irrigant in the peritoneal cavity after implantation with Walker 256 cells.
A systemically acting agent such as A8103 has an obvious
McKIBBIN B. Destruction of Malignant Cells in Peritoneal CavityExperimental Use of a Chemotherapeutic Agent. Arch Surg. 1964;89(4):691-694. doi:10.1001/archsurg.1964.01320040107018