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March 1965

Acceleration of Open Wound Healing by Cartilage

Author Affiliations

From the Department of Surgery, State University of New York, Downstate Medical Center.

Arch Surg. 1965;90(3):414-417. doi:10.1001/archsurg.1965.01320090092021

IN 1957 the acceleration in gain of tensile strength in wounds treated with heterologous cartilage powder was established by Prudden.1 Since that time this phenomenon has been documented by many studies.2-5 Attempts to find the active ingredient(s) in the cartilage powder have been unsuccessful, but substances with a chemical resemblance to cartilage (talcum powder, bone flour, chondroitin sulfate, chondromucoprotein, and Moss' bone extract) do not have the wound-stimulating property6 and bespeak the specificity of the repair stimulating factor in cartilage. That this factor can be transported via the blood stream has been shown by two studies. Prudden et al7 showed that the subcutaneous implantation of pellets of tracheal cartilage three to five days prior to making incised wounds significantly accelerated the healing of these wounds. In a second study he found that parenteral administration of a saline extract of cartilage powder exerted a similar effect on

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