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Article
March 1965

A Single-Anastomosis Heterotopic Cardiac Homotransplant

Author Affiliations

NEW HAVEN, CONN
From the Department of Surgery, Yale University, School of Medicine. Assistant Professor of Surgery (Dr. Stansel); Assistant Resident in Surgery (Dr. Terino).

Arch Surg. 1965;90(3):444-448. doi:10.1001/archsurg.1965.01320090122026
Abstract

HOMOTRANSPLANTATION of the canine heart has been studied by many investigators over the past 60 years. Carrel and Guthrie, in 1905, were the first to report successful transplantation of a puppy heart which functioned for two hours in the neck of the recipient.1 In general, three differing surgical and physiological methods have been utilized: (1) The systemic circulation of the recipient has been used to perfuse the coronary circulation of the homotransplant. (2) The transplant's cardiac output supplies its own coronary arterial flow. (3) A donor heart, sometimes with the lungs, has been transplanted orthotopically to replace these vital organs, both anatomically and functionally.

Perfusion of the homograft coronaries via a host artery was used by Carrel,1 Mann and co-workers2 in 1933, Marcus et al3 in 1951, Downie4 in 1953, Wesolowski5 in 1953, Sayegh and Creech6 in 1959, Reemtsma et al7 in

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