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March 1965

A Single-Anastomosis Heterotopic Cardiac Homotransplant

Author Affiliations

From the Department of Surgery, Yale University, School of Medicine. Assistant Professor of Surgery (Dr. Stansel); Assistant Resident in Surgery (Dr. Terino).

Arch Surg. 1965;90(3):444-448. doi:10.1001/archsurg.1965.01320090122026

HOMOTRANSPLANTATION of the canine heart has been studied by many investigators over the past 60 years. Carrel and Guthrie, in 1905, were the first to report successful transplantation of a puppy heart which functioned for two hours in the neck of the recipient.1 In general, three differing surgical and physiological methods have been utilized: (1) The systemic circulation of the recipient has been used to perfuse the coronary circulation of the homotransplant. (2) The transplant's cardiac output supplies its own coronary arterial flow. (3) A donor heart, sometimes with the lungs, has been transplanted orthotopically to replace these vital organs, both anatomically and functionally.

Perfusion of the homograft coronaries via a host artery was used by Carrel,1 Mann and co-workers2 in 1933, Marcus et al3 in 1951, Downie4 in 1953, Wesolowski5 in 1953, Sayegh and Creech6 in 1959, Reemtsma et al7 in

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