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July 1965

Activities of Transplanted Gastric Mucosa in the Totally Gastrectomized AnimalAn Experimental Study

Author Affiliations

From the West Virginia University Medical Center and the VA Hospital. Professor of Surgery, West Virginia University Medical Center and Chief of Surgery, VA Hospital (Dr. Gerwig); Professor and Chairman, Department of Surgery, West Virginia University Medical Center (Dr. Zimmermann); Staff Surgeon, VA Hospital and Instructor in Surgery, West Virginia University Medical Center (Dr. Mendoza); Resident in Surgery, VA Hospital and West Virginia University Medical Center (Dr. Lee); Chief of Medicine, VA Hospital and Clinical Professor of Medicine West Virginia University Medical Center (Dr. Jones); and, Veterinarian Consultant, Research Laboratory, VA Hospital (Dr. Hooton).

Arch Surg. 1965;91(1):161-164. doi:10.1001/archsurg.1965.01320130163018

Transplanted tissue will grow only if there is a lack of that tissue in the host.

Halsted's Law

M ANY patients when deprived of all or a major portion of their stomachs are confronted with troublesome sequelae. Among the physiological changes suggested as responsible for some of these difficulties are such factors as mechanical, metabolic, functional, inflammatory, and hematologic.1,2 Attempts to overcome the mechanical factors have been widespread. In recent years numerous substitute pouches have been suggested.3-11 A long-term follow-up12 has indicated that the creation of a substitute pouch may possess some benefits but will by no means completely alleviate all postgastrectomy problems. Especially is this true in regard to loss of weight.

Previous experiments carried out in our laboratory have shown that the stomach may be relocated in the abdominal cavity as a pouch, yet continue to exert some salutary effects. It was concluded from these

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