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August 1965

Preservation of Kidneys for TransplantationAn Experimental Study

Author Affiliations

From Mayo Clinic and Mayo Foundation, sections of surgical research (Dr. Hallenbeck), experimental and anatomic pathology (Dr. Shorter), clinical pathology (Dr. Owen), and medicine (Dr. Hunt). Resident in Nephrology Mayo Graduate School of Medicine (Dr. Baitz), and Resident in Surgery, (Dr. Scott).

Arch Surg. 1965;91(2):276-287. doi:10.1001/archsurg.1965.01320140066011

IN THE course of clinical renal transplantation, a period of renal ischemia is inevitable. When living donors are used, the time the kidney is without blood flow can be kept short enough that damage from ischemia is minimal. Use of cadaveric kidneys introduces longer and more variable periods of renal ischemia and makes damage to the kidneys from this cause a more serious problem. The solution to the problem requires, first, that kidneys be obtained in the best possible condition and, second, that once the kidneys are removed, further deterioration be slowed as much as possible until renal blood flow can be established in the recipient. The present study was performed to assess the importance of the duration of the initial period of ischemia in determining subsequent function of canine kidneys and to compare the effectiveness of cooling alone, of cooling in an environment of hyperbaric oxygen, and of normothermic

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