September 1965

Pericolic Granuloma

Author Affiliations

From the Department of Surgery, Northwestern University Medical School, Passavant Memorial Hospital, Chicago Wesley Memorial Hospital, and Cook County Hospital.

Arch Surg. 1965;91(3):407-412. doi:10.1001/archsurg.1965.01320150037005

GRANULOMAS develop at any level in the gastrointestinal tract where mucosal defect has occurred. A focus of infection results which becomes surrounded by an intense inflammatory response. Central necrosis and abscess formation are often present.

In the colon, most granulomas are associated with acute and chronic diverticulitis, although the lesion may develop in a segment of colon which otherwise appears normal.

This report includes a description of ten cases (Table 1) which demonstrate the diverse clinical and pathological features of pericolic granuloma. Each lesion consisted of a localized inflammatory mass which involved the colon and adjacent mesentery. A central cavity which contained purulent exudate or fecal material was usually present. The correct diagnosis was not established until the entire specimen was available for histologic study. Two illustrative cases are described here in detail.

Report of Cases 

Case 5.  —A 31-year-old white woman was hospitalized on May 11, 1962, with intermittent

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