THE biological challenge that an extensive full-thickness burn creates on a living organism varies with the different phases of its evolution.20 It has been well established that the interval from time of injury to the complete cover of the open wound by new skin is one of the key factors in the survival rate.20 The recovery correlates closely if it does not actually depend upon achieving a positive nitrogen balance.20 This balance becomes negative whenever there is a large open wound as with a large uncovered fullthickness burn resulting in a progressive loss of nitrogen which is reversed only by covering the wound with skin; failure to do so will result in chronic infection, progressive malnutrition, and general deterioration of the burned patient.20 When the nitrogen balance is severely altered, the wound may reject the new skin making the cover almost impossible.
The separation between the
DEYSINE M, CLARKE RL, CLIFTON EE. Treatment of Experimental Burns With Systemic Human Fibrinolysin. Arch Surg. 1965;91(3):526-529. doi:10.1001/archsurg.1965.01320150156032