September 1965

Prenatal Induction of Homograft Tolerance

Author Affiliations

From the Sansum Research Foundation, Santa Barbara, Calif.

Arch Surg. 1965;91(3):534-536. doi:10.1001/archsurg.1965.01320150164034

THE MORE advanced species of mammals, including man, are born with a competent immunological protective mechanism already well developed. They will not accept tissues transplanted from other individuals of the same or different species. Animals born at a comparatively earlier stage of physical development, such as some species of mice and rats, do not possess at birth the mature immunological reactivity necessary to be able to distinguish between their own tissues and that of others. Implantation of tissue such as living spleen cells from another individual at this early age results in a permanent tolerance not only for the spleen cells but also for other tissues of the same donor.1,2 Or placing a prospective donor in parabiotic union with the recipient at an early age allows a cross mixture of blood which renders the two parabionts permanently tolerant to each other, so that many months after separation of the

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