METHODS used in the past to study the peripheral circulation in man have included oscillometry, plethysmography, controlled walking tests, recording changes in skin temperature, methods for releasing nervous vasoconstrictor activity, angiography, and disappearance rates for radioactive substances injected into muscle.2 Despite this long list a simple, yet accurate method for studying and quantifying blood flow to the muscle mass of an extremity is still lacking. Objective means of measuring the deep circulation of an extremity and the effect of revascularization procedures have not been available.
This paper describes further studies of radioisotope scanning, using macroaggregated iodinated I131 serum albumin (Albumotope LS)* to study the regional blood flow to normal and diseased extremities.5
Macroaggregated iodinated I131 serum albumin was prepared initially from a 0.1 to 1% solution of iodinated I131 serum albumin (Albumotope) in a 0.9% sodium chloride solution, carefully adjusted to a pH of 5.5, the isoelectric
JONES EL, WAGNER HN, ZUIDEMA GD. New Method for Studying Peripheral Circulation in Man. Arch Surg. 1965;91(5):725-734. doi:10.1001/archsurg.1965.01320170019004