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November 1965

Regional Blood Flow During Pulsatile and Nonpulsatile Perfusion

Author Affiliations

From the departments of surgery and physiology, Indiana University School of Medicine.

Arch Surg. 1965;91(5):771-774. doi:10.1001/archsurg.1965.01320170065010

DIFFERENCES in response to pulsatile and nonpulsatile blood flow might be important during total cardiopulmonary bypass, assisted circulation, and with regard to implantable mechanical hearts.

In previous studies from this laboratory, nonpulsatile flow was found to be associated with increased systemic vascular resistance as compared with pulsatile flow.1 In the present investigation, renal, hepatic, and hind-limb flows were determined during total body pulsatile and nonpulsatile perfusion in dogs.

Method  1. Ten healthy mongrel dogs, each weighing 12 to 22 kg (26.4 to 48.4 lb) were anesthetized lightly with intravenous 5% thiopental (Pentothal). Adequate ventilation with oxygen was maintained by use of a mechanical respirator connected to an endotracheal tube. The animals were given 2 mg/kg sodium heparin. A polyethylene catheter was inserted into a femoral artery and another was placed in the left innominate vein through the left jugular vein. They were connected to individual strain gauges, and systemic

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