December 1965

Renal Allotransplantation and Allantoin Excretion of Dalmatian

Author Affiliations

From the Department of Surgery, Stanford University, School of Medicine.

Arch Surg. 1965;91(6):911-912. doi:10.1001/archsurg.1965.01320180045011

IN MAN the predominant end-product of purine catabolism is uric acid which is excreted in the urine. In subprimates the greater part of the uric acid formed is further degraded to allantoin through the action of an oxidizing enzyme, uricase. The allantoin is then excreted in the urine.1

The Dalmatian dog, unlike other mammals, excretes more uric acid in proportion to its body size than does man although its plasma levels are only 10% to 20% as high as man's.1 This is not due to any deficiency of uricase in the Dalmatian's liver,2 but is said to be a renal phenomenon caused by a failure in resorption of uric acid by the kidney tubules. Though this defect was originally presumed to be a simple absence of the proximal tubular resorption mechanism,3 subsequent investigation showed that the usual resorption of uric acid can be replaced under some

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