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December 1965

Experimental Hypothermia of Urinary BladderA Morphologic Study

Author Affiliations

From the departments of obstetrics-gynecology and pathology, University of Rochester School of Medicine and Dentistry.

Arch Surg. 1965;91(6):913-919. doi:10.1001/archsurg.1965.01320180047012

CRYOSURGERY, the technique of surgical destruction of tissue by freezing, is finding ever-increasing application. Freezing of the stomach by means of a balloon through which a coolant is circulated has been utilized both experimentally and clinically, and suggested the possibility of applying this technique in other viscera. Because of our interest in evaluating the effects of freezing the pelvic viscera, the urinary bladder was chosen for this study. An evaluation of the potential clinical usefulness of cryosurgery must be based on the consideration of the acute and chronic effects of freezing on normal morphology and function. Our study was designed to investigate the morphologic alterations induced in the normal bladder.

Method  Laparotomy by suprapubic incision was performed on 13 adult mongrel dogs weighing 20 to 40 kg (44 to 88 lb). Sodium pentobarbital was used as anesthesia.Thermistor needle probes were placed in the rectum, esophagus, pelvic basin, and in

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