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December 1965

Fluorouracil Toxicity Following Gastrointestinal Surgery

Author Affiliations

From the departments of medicine and surgery and the pathology service, Letterman General Hospital.

Arch Surg. 1965;91(6):1002-1004. doi:10.1001/archsurg.1965.01320180136028

FLUOROURACIL has been widely used as a palliative adjunct for several types of malignancy, especially those of the gastrointestinal tract. Toxic effects are not uncommon and those relating to the gastrointestinal system are especially troublesome.1 This case presents an unusual manifestation of gastrointestinal involvement in that only the "bypassed" portion of the colon, following side-to-side ileo descending colostomy, showed a toxic response.

Report of Case  A 53-year-old man was admitted to the hospital on Oct 14, 1964. He complained of left upper quadrant abdominal pain without other gastrointestinal symptoms. There had been a 25 lb (11.3 kg) weight loss in the preceeding six months.Findings of a physical examination were normal except for a tender mass in the right upper quadrant which extended 6 cm below the costal margin in the midclavicular line.Blood count and results of urinalysis and chest roentgenogram were normal. Sulfobromopthalein retention was 27% in

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