PRIMARY malignant lymphoma of the colon and appendix is rare. Reports on this subject are often confused and difficult to evaluate inasmuch as many authors have considered the entire gastrointestinal tract when discussing this type of neoplasm. In addition, in most instances, no attempt has been made to exclude patients with evidence of partial or generalized involvement of the reticulo-endothelial system. The problem is further compounded by the confusion that has existed concerning the classification of malignant neoplasms of the reticuloendothelial system.
This paper presents experiences with 27 carefully selected cases of primary malignant lymphoma of the colon (exclusive of the rectum) and appendix in patients who, at operation, manifested no evidence of spread beyond the confines of the colon, immediately adjacent ileum, or appendix and the immediate regional lymph nodes.
Involvement of the gastrointestinal tract by malignant lymphoma has been recognized since the earliest description of the disease
GLICK DD, SOULE EH. Primary Malignant Lymphoma of Colon or AppendixReport of 27 Cases. Arch Surg. 1966;92(1):144-151. doi:10.1001/archsurg.1966.01320190146033