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Article
April 1966

Chronic OsteomyelitisTreatment by Regional Perfusion With Antibiotics

Author Affiliations

MILWAUKEE
From the Division of Surgery, Marquette University School of Medicine, and the Cancer Diagnostic and Research Center, St. Mary's Hospital, Milwaukee.

Arch Surg. 1966;92(4):548-553. doi:10.1001/archsurg.1966.01320220104017
Abstract

REGIONAL perfusion, first described by Creech and co-workers in 1958,1 with cancer chemotherapeutic agents for neoplastic diseases is a method of delivering to the area of disease, a concentration of the antineoplastic drug that would not ordinarily be tolerated systemically as well as delivering a significantly greater concentration of the drug per unit weight of tumor. A similar technique using antibiotics was also described by Ryan et al2,3,4 and has been explored and evaluated over the past six years in our clinic. A number of clever and seemingly useful modifications of the regional approach to treatment have been discussed and described (antitoxin perfusions for snake bite; antifungal perfusion for localized fungus disease [coccidioidomycosis and blastomycosis]) since the application of the extracorporeal pump circuit was first described

The perfusion method of treatment for osteomyelitis is an obvious choice to be explored since the disease represents a localized involvement of

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