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May 1966

Surgical Thyroid DiseaseA Survey Before and After Iodine Prophylaxis

Author Affiliations

From the Department of Pathology, The University of Michigan, Ann Arbor.

Arch Surg. 1966;92(5):796-801. doi:10.1001/archsurg.1966.01320230144026

THERE HERE HAS been an observed change in the frequency of various surgical diseases of the thyroid gland. The number of patients with thyrotoxicosis and nodular colloid goiter are declining,1-4 while there has been an increase in the incidence of thyroid carcinoma5,6 and thyroiditis, especially Hashimoto's type.2,3,7,8

The etiologic factors related to this change have not been elucidated. One of the agents which should be considered is iodine. In contrast to the body of knowledge related to the metabolic and functional significance of iodine to the thyroid gland, our knowledge of the effect of iodine, particularly the effect of excess iodine, on the human thyroid gland may be said to be in a nescient state.

The purpose of this report is twofold: (1) to describe the changing incidence of surgical thyroid diseases seen at The University of Michigan Medical Center over a 20-year period, and (2) to

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