[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.216.242. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
July 1966

Effects of Histamine, Feeding, and Insulin Hypoglycemia on Net Ionic Fluxes in Gastric Pouches

Author Affiliations

MONTREAL
From the University Surgical Clinic, the Montreal General Hospital, and McGill University, Montreal.

Arch Surg. 1966;93(1):175-181. doi:10.1001/archsurg.1966.01330010177022
Abstract

INTEREST in the secretion of acid and pepsin by the gastric mucosa has overshadowed a secondary but equally challenging property of this complex physiological area. Acid which is secreted must be contained within the lumen of the stomach for a sufficient period of time to allow for acid peptic digestion. The ability to contain an acid solution against a high concentration gradient is an essential function of the mucosa of the stomach, a function made possible by the existence of a barrier which prevents the reabsorption of hydrogen ions from the lumen into the interstitial tissues. Hydrogen and sodium ions both compete for the same limiting mechanism by which they would be able to leave the lumen; but hydrogen ions are greatly favored over sodium and the loss of sodium from a nonsecreting stomach containing an acid solution is small in proportion to that of hydrogen.1 The importance of

First Page Preview View Large
First page PDF preview
First page PDF preview
×