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October 1966

Aortic Homograft Preservation With Dimethyl Sulfoxide

Author Affiliations

From the departments of surgery and pathology of the University of Missouri, Columbia.

Arch Surg. 1966;93(4):656-658. doi:10.1001/archsurg.1966.01330040120022

THIS REPORT defines a technique of arterial homograft preservation. It does not attempt to evaluate different arterial grafting materials nor does it evaluate the long-term problems of implanted arterial homografts.

The first homograft implant was carried out in the dog by Höpfner.1 In 1910 Carrel2 reported results of his investigations in the use of preserved homografts. His preservation techniques included the use of physiological saline solution, Locke's solution, serum, and defibrinated dog's blood at refrigerator temperatures and at temperatures of −3 C. Carrel also attempted desiccating the arteries over calcium chloride and later reconstituting them in Locke's solution. Levin3 attempted preservation of aortas in formaldehyde solution (formalin). The report of Gross4 and his associates in 1949 of homografts stored at 4 C in 10% homologous serum electrolyte solution revived interest in the arterial homograft. Hufnagel,5 Deterling,6 and Meeker and Gross7 studied techniques for

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