[Skip to Content]
[Skip to Content Landing]
Article
December 1966

Substances in Sera Influencing Growth of Sarcoma 180 in Mice

Author Affiliations

CHICAGO
From the Department of Surgery, University of Illinois College of Medicine, Chicago.

Arch Surg. 1966;93(6):967-970. doi:10.1001/archsurg.1966.01330060111012
Abstract

IN 1953 John Kidd1 reported a series of experiments showing that subcutaneous mouse lymphomata of two types regressed promptly following intraperitoneal injection of normal guinea pig serum into the mice. The tumor grew normally in untreated controls and in mice injected with rabbit or horse serum. The guinea pig serum had no discernible effect on the tumor cells in vitro. This was the first report of a naturally occurring substance which would cause tumor regression in a single type of cancer without harm to the injected animal.

The experiments reported in this paper were designed to assess the effects of direct contact between sarcoma-180 cells and various animal and human sera on the growth of and immunologic reactions to this tumor in mice. Kidd's experiments suggested that incubation of cancer cells with foreign sera, especially guinea pig serum, might cause the cells to become inactive without discernible effects on

First Page Preview View Large
First page PDF preview
First page PDF preview
×