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January 1967

Endotoxin ShockHemodynamic and Survival Effects of Methylprednisolone

Author Affiliations

From the Veterans Administration Hospital, and the departments of surgery and physiology, University of Oklahoma Medical Center, Oklahoma City.

Arch Surg. 1967;94(1):61-66. doi:10.1001/archsurg.1967.01330070063014

THE USE of corticosteroids in shock is a subject of much recent interest.1-15 Although varied claims have been made for the effectiveness of these agents in shock, there appear to have been no adequately controlled studies in clinical shock.16 There is evidence that corticosteroids are protective to dogs4,7,8,11 and other animals1-3 in endotoxin shock. Different theories about the protective actions of steroids have been advanced based on clinical and animal studies.4,11,13,17-20

The present study was designed to investigate the survival and early hemodynamic effects of the synthetic corticosteroid, methylprednisolone sodium succinate (Solu-Medrol), on pulmonary and peripheral vascular beds when administered to dogs following an 80% lethal dose of Escherichia coli endotoxin.

Methods  Experiments were carried out on 82 adult mongrel dogs of both sexes, anesthetized with sodium pentobarbital, 30 mg/kg body weight, administered intravenously. A series of survival experiments was carried out on 30 dogs

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