February 1967

Influence of Hypothermia on the Course of Experimental Pancreatitis

Author Affiliations

Buffalo, NY
From the Department of Surgery, State University of New York at Buffalo and the E. J. Meyer Memorial Hospital, Buffalo. Dr. Eichelter is a Buswell Fellow in Surgical Research and is presently with the Second University Surgical Clinic, Vienna, Austria.

Arch Surg. 1967;94(2):280-285. doi:10.1001/archsurg.1967.01330080118029

THE CONTINUED high mortality from acute pancreatitis in man indicates the need for improved treatment of this poorly understood condition. Experimental pancreatitis has most commonly been produced in the past by forceful injection of bile and other materials into the pancreatic ducts. However, this has not produced a pancreatitis duplicating that seen in man. Recently McCutcheon and Race1 have shown that the construction in the dog of a blind duodenal loop communicating with the pancreatic ducts, as earlier described by Pfeffer et al2 results in a pancreatitis very similar to that seen in man. Symbas and associates3 and Veghelyi and associates4 have supplied evidence that pancreatic secretion and enzyme activity are reduced in dogs in response to hypothermia. Earlier reports concerning the influence of hypothermia on the course of experimental pancreatitis have been conflicting.5-8 However, these experiments had, in general, the common objection of the

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