June 1967

Injection of 5% Phenol Into Submucosa of Denervated Gastric Pouch

Author Affiliations

Memphis, Tenn
From the departments of anatomy and surgery, School of Basic Medical Sciences and School of Medicine, University of Tennessee Medical Units, Memphis.

Arch Surg. 1967;94(6):841-844. doi:10.1001/archsurg.1967.01330120095017

EARLY IN the work with histamine, it was reported by Popielski1 and by Keeton and associates2 that this drug produced a gastric secretory response after section of the vagus nerves to the otherwise intact stomach. Ivy and Javois3 found that histamine would stimulate gastric secretion in a denervated gastric pouch and Klein4 reported that a similar response could be obtained from a transplanted gastric pouch that had been deprived of its muscular layers and myenteric plexus. In 1948, Oberhelman and Dragstedt5 noted that the gastric secretory response to a standard dose of histamine in dogs with a totally isolated stomach pouch was markedly reduced (44% to 77%) following bilateral vagotomy; and in 1961, Gelb and associates6 reported that the maximal histamine response in patients studied before and after vagotomy was reduced 59% to 93%. In 1964, Anderson and Olbe7 reported that vagal denervation

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