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June 1967

Giant Cell Carcinoma of the LungReview of Literature and Report of Five Cases

Author Affiliations

From the Department of Surgery, Pennsylvania Hospital, Philadelphia.

Arch Surg. 1967;94(6):891-894. doi:10.1001/archsurg.1967.01330120145028

BEFORE Nash and Stout1 reported, in 1958, a variant of lung cancer that they considered to be a new histopathologic entity, the accepted classifications of primary lung carcinomas had been (1) epidermoid, (2) adenocarcinoma, (3) undifferentiated (small or large cell), and (4) mixed (formed of elements of other three types).2 Nash and Stout termed their tumor "giant cell carcinoma" and reported five cases. Since then, Metropol et al3 have reviewed the literature into early 1965 and reported finding two more cases. The present communication adds six more case reports.

Report of Cases 

Case 1.  —A 58-year-old man was admitted to Pennsylvania Hospital on Aug 21, 1963. He was asymptomatic, but a chest x-ray film had shown a "fibrotic lesion" in the right upper lobe. The only significant finding in his history was surgery for papillary cancer of the bladder six years previously. He admitted smoking from one

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