Still, if microcirculation fails, tissue nutrition is impaired and cardiovascular repair becomes futile.—deTakats1
PERIPHERAL tissue oxygenation is poor in patients with single or multiple arterial occlusions which produce symptomatic ischemia. Distal blood flow is sluggish, the viscosity of capillary blood is increased, and the arteriolar pressure decreased. A self-perpetuating cyclic worsening of the ischemia develops and progresses until tissue necrosis supervenes.
When distal arterial reconstruction is anatomically impossible or physiologically unsupportable, indirect means of augmenting microcirculatory flow becomes desirable. Heparinization has been utilized and found to be effective in forestalling irreversible tissue necrosis. Administration of dextran 40 has been utilized and shown to be beneficial by some in treatment of acute arterial occlusion.2 Similarly, vasospastic and traumatic ischemia has been favorably influenced by infusion of dextran 40.3 Even the ischemia of fat embolism has been satisfactorily treated using low molecular weight dextran.4
However, these clinical
Moraes I, Teixeira E, Arbit J, Bergan JJ. Augmentation of Arterial Collateral Blood Flow. Arch Surg. 1967;95(1):49-53. doi:10.1001/archsurg.1967.01330130051010