ESTROGEN-SECRETING carcinomas of the adrenal cortex are a relatively unusual cause of feminization in males, but they have proven to be highly malignant tumors and to yield extremely poor survival statistics.1 In addition, they are relatively insensitive to irradiation and chemotherapy. It seems, therefore, that well-planned and executed radical extirpative surgery offers these patients the best opportunity for survival. In accordance with this premise, the 54th reported case of feminizing adrenal carcinoma was recently treated at the Wilford Hall US Air Force Hospital, Tex.
Report of a Case
A 35-year-old white male navigator was admitted to the Urology Service of the Wilford Hall USAF Hospital for evaluation of gynecomastia. Tight-fitting parachute straps had called his attention to breast tenderness approximately one year prior to admission, and subsequently he had noted progressive breast enlargement. There was no history of decrease in libido, impotence, pain, weight loss, or other symptoms.
Polis CT, Woodhead DM. Radical Thoracico-abdominal Adrenalectomy and LymphadenectomyTreatment for Feminizing Carcinoma. Arch Surg. 1967;95(2):181-184. doi:10.1001/archsurg.1967.01330140019005