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August 1967

Protection Against the Toxic Action of Oxygen at High PressureEffect of Sodium Succinate on Ehrlich Ascites Cells

Author Affiliations

Ann Arbor, Mich
From the Department of Physiology, University of Michigan, Ann Arbor.

Arch Surg. 1967;95(2):185-188. doi:10.1001/archsurg.1967.01330140023006

PREVIOUS experiments have shown that in vitro exposure of suspensions of Ehrlich ascites tumor cells to oxygen at high pressure (OHP) causes cellular damage as indicated by vital dyes and that this damage can be irreversible, so that subsequent inoculation of these cells into normal mice fails to induce the disease.1 Other investigators2 have reported that the administration of sodium succinate (NAS) to rats prior to their exposure to OHP prevents the toxic action of OHP on these animals as indicated by the absence of overt central nervous system (CNS) effects including the typical oxygen convulsions, and by the survival of all of the exposed animals. The experiments herein described were undertaken in an attempt to determine what influence, if any, NAS might have on the toxic action of OHP on ascites cells mentioned above with expectation that such information might help explain the lethal action of OHP

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