[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.9.146. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 1967

The Nature and Source of a Gastric SecretagogueObservations From the Obstructed Portal Vein

Author Affiliations

Toronto
From the Department of Surgery, University of Toronto.

Arch Surg. 1967;95(4):606-608. doi:10.1001/archsurg.1967.01330160076009
Abstract

IT IS well known that gastric hypersecretion occurs in dogs with portacaval shunts.1-6 For the most part, this hypersecretion has been measured only after the dogs had stabilized for 30 days postoperatively. While constructing portacaval shunts in dogs with Heidenhain pouches, an immediate and marked pouch secretion was noted. This hypersecretion decreased over the following 24 hours and stabilized above preshunt levels. It seemed that a gastric secretagogue had accumulated in the obstructed portal vein while the shunt was being constructed; this "early" hypersecretion was investigated in dogs.

Methods 

Confirming the Presence of a Secretagogue in Portal Blood.  —The portal vein was clamped for 30 minutes in 18 mongrel dogs anesthetized with pentobarbital (Nembutal). Major portal-systemic shunts were eliminated by clamping the vessels in the rectosigmoid area and at the cardiac end of the stomach. There were 50 cc of occluded portal blood, anticoagulated with 5 cc of sodium

First Page Preview View Large
First page PDF preview
First page PDF preview
×