October 1967

Disposable Aerosol Tissue Adhesive Spray

Author Affiliations

USA; USA; USA, Washington, DC
From the Division of Surgery, Walter Reed Army Institute of Research, (Drs. Matsumoto and Hardaway) and the US Army Medical Biomechanical Research Laboratory, Walter Reed Army Medical Center (Drs. Pani and Margetis) Washington, DC.

Arch Surg. 1967;95(4):685-688. doi:10.1001/archsurg.1967.01330160155024

THE successful surgical application of various higher homologous cyanoacrylate monomers using new surgical techniques1-5 has been reported. The spray gun6 used in these studies permitted delivery of a fine spray which forms homogenous, uniform surface cover with a minimum volume of adhesive. However, the spray gun required cautious and time-consuming cleaning of its nozzle and Teflon tip with nitromethane after each procedure. The purpose of this paper is to describe the development of an aerosol spray unit which simplifies the use of cyanoacrylate tissue adhesives and to evaluate the feasibility of mixing cyanoacrylate monomers with various Freon compounds.

Materials and Methods  Various cyanoacrylate monomers and Freon compounds were combined in a wide variety of ratios (Table). Gas chromatographic observations of monomer and monomer-Freon mixtures are made. After selecting monomers, containers were constructed. Various actuators which provided different discharge rates were selected. Monomer and Freon were mixed in 30-cc

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