IN clinical applications, Smith1 confirmed theoretic expectations of hyperbaric oxygenation in treatment of patients with carbon monoxide intoxication. Of 70 patients with carbon monoxide poisoning treated with oxygen under pressure by Smith and Sharp,2 only two died. Both had been slowly poisoned by gas over intervals of at least eight hours.
Carbon monoxide occurs in the home through leakage of manufactured gas from open burners and defective appliances and from incomplete oxidation of commercial gas products. Carbon monoxide fumes may be found in the coal mining and steel industry, in gas manufacturing, and in use of explosives in closed places, as well as in smoke, in enclosed spaces that have been painted with oil paints, and in the exhaust of internal combustion engines. Carbon monoxide poisoning from motor exhaust gas in closed garages has been responsible for many suicides and accidental deaths.
Two brothers with acute carbon monoxide
Kokame GM, Shuler SE. Carbon Monoxide PoisoningTreatment by Hyperbaric Oxygenation. Arch Surg. 1968;96(2):211-215. doi:10.1001/archsurg.1968.01330200049007