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Article
February 1968

Pheochromocytoma of the BladderDetection by a New Screening Test

Author Affiliations

Ann Arbor, Mich
From the departments of pathology (Drs. Batsakis, Brody, and Rice) and surgery (Dr. Bartlett), at the University of Michigan Medical Center, Ann Arbor, Mich.

Arch Surg. 1968;96(2):254-258. doi:10.1001/archsurg.1968.01330200092017
Abstract

ORIGIN in the urinary bladder of a pheochromocytoma is an unusual experience of an uncommon neoplasm. Of all pheochromocytomas 5% to 10% are extra-adrenal1 and to date, 24 cases of this neoplasm in the bladder have been reported.

While it is true that certain features of diagnostic import have been shown to predominate in patients with pheochromocytoma of the bladder,2preoperative substantiation is achieved by biochemical means. This confirmation is of more than academic interest when one considers the high mortality associated with surgical procedures on undiagnosed pheochromocytomas regardless of their location.

Since 1950 when Engel and von Euler3 reported an increased urinary content of noradrenaline and adrenaline in two patients with pheochromocytoma, there has been an extensive recording of developments and assessments of biochemical tests for the diagnosis of this disease. One pressing need, however, remains unfulfilled. A clinicallly satisfactory screening test for pheochromocytoma has yet

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