VITAMIN K is essential for the formation of prothrombin, one of the factors in human blood clotting. Vitamin K, a fat soluble vitamin, is readily available in a normal adult diet and also is abundantly produced by putrefactive bacteria in the mammalian intestine. It is apparent that if the exogenous sources of the vitamin are absent or if its absorption is prevented, hypoprothrombinemia may develop. Various antibiotics may also block vitamin K activity in the hepatic cell. Hypoprothrombinemia may be manifested by massive gastrointestinal hemorrhage as is illustrated by the following cases.
Report of Cases
—A 54-year-old white woman was admitted to St. Luke's Hospital with signs and symptoms compatible with intestinal obstruction. Her laboratory work-up on admission included a prothrombin level of 100%. She was explored the same day and the distal ileum and cecum were resected because of obstruction due to regional enteritis. Intestinal continuity was
Klippel AP, Pitsinger B. Hypoprothrombinemia Secondary to Antibiotic Therapy and Manifested by Massive Gastrointestinal HemorrhageReport of Three Cases. Arch Surg. 1968;96(2):266-268. doi:10.1001/archsurg.1968.01330200104020