ONE OF the major deterrents to routine clinical application of the transplantation of organs is the problem of obtaining functioning organs in sufficient numbers from cadaveric sources. A central feature of any program designed to procure suitable cadaveric organs is the capability of preserving such organs in a functional state for a reasonable interval. An effective method of storing organs must meet the following requirements: (1) available within a few minutes after the death of a potential donor; (2) portable to move easily and quickly over an area within 50 miles of the transplanting hospital; (3) effective for at least 24 hours to allow time for the preparation of the recipient and essential histocompatibility tests; and (4) prevent functional deteriorization of the organ during its interval of preservation and be easily applicable to the heart, lung, liver, and pancreas as well as the kidney.
Our experiences in attempting to develop
Stevens LE, Iverson BM, Reemtsma K. The Preservation of Kidneys by in Vitro Perfusion. Arch Surg. 1968;96(4):540-544. doi:10.1001/archsurg.1968.01330220056010