IN SEPTEMBER 1894, a dermatologist, Caesar Boeck,1 examined a 36-year-old policeman at the University Polyclinic of Christiana, Norway. The man had skin lesions on the face, arms, and some parts of the trunk. These were small, slightly elevated nodules; the smaller ones were yellow or brown, and the larger ones were bluish red. There was enlargement of many lymph nodes. Two nodules were excised and Professor Boeck summarized the microscopic findings as follows:
The histology was also unique. The areas of new growth might be described as perivascular sarcomatoid tissue built up by excessively rapid proliferation of epitheloid connective-tissue cells in the perivascular lymph spaces.... it should be remembered that true giant cells of sarcomatous type were found, though rarely.
The patient was treated with arsenic, wine of iron and quinine, and cod liver oil. By 1899, the lesions had largely resolved, leaving some areas of pigmentation, and the
Lam CR. The Surgical Aspects of SarcoidosisWith Particular Reference to Some Apparent Cures Following Surgical Procedures. Arch Surg. 1968;97(3):459-468. doi:10.1001/archsurg.1968.01340030119011