March 1969

Tissue Adhesive and Wound HealingObservation of Wound Healing (Tissue Adhesive vs Sutures) by Microscopy and Microangiography

Author Affiliations

Washington, DC
From the Division of Surgery (Drs. Matsumoto, Soloway, and Hamit), Walter Reed Army Institute of Research, and the Department of Oral Pathology (Dr. Cutright), US Army Institute of Dental Research, Walter Reed Army Medical Center, Washington, DC.

Arch Surg. 1969;98(3):266-271. doi:10.1001/archsurg.1969.01340090042003

Reports indicate that cyanoacrylate tissue adhesive offers many advantages when used for repair or hemostasis of injured organs.1-5 Hatung6 reported that comparisons of tensile strength and histology of wounded skin and parenchymal organs revealed that closure with methyl-2-cyanoacrylate or n-butyl cyanoacrylate monomers gave results superior to those obtained by conventional suturing in wounds of parenchymatous organs but not in those of skin. However, no morphological study of wound healing in which tissue adhesive was used has been reported. The purpose of this study was to evaluate healing of wounds repaired with cyanoacrylate in the liver, kidney, and skin, by use of microscopy and microangiography.

Materials and Methods  Fifteen dogs of both sexes ranging from 9 to 14 kg (20 to 31 lb were used. All dogs were fed a normal laboratory diet and given water freely. The principles of laboratory animal care as promulgated by the National

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