March 1969

Endocrine Function of Pancreatic Homotransplants in DogsThe Effect of Immunosuppressive Therapy

Author Affiliations

Paris; Montreal; Paris; Denver
From the departments of surgery and medicine, University of Colorado School of Medicine and the Denver Veterans Administration Hospital, Denver, and the Department of Pathology, Hospital Saint-Antoine, University of Paris, Paris.

Arch Surg. 1969;98(3):375-380. doi:10.1001/archsurg.1969.01340090151030

The ability of the transplanted pancreas to restore normal blood glucose levels in the pancreatectomized dog was demonstrated first by Gayet and Guillaumie 40 years ago.1 The first successful pancreatic homotransplants using vascular anastomosis were reported by De Jode and Howard in 1962.2 Within the past few years, several experimental studies have emphasized the technical problems related to pancreatic transplantation, the methods of detecting the onset of rejection and the difficulties of preventing this process with immunosuppressive agents.3-10

The present study has two objectives: first, to evaluate the endocrine function of partial and total duodenopancreatic homotransplants at different postoperative stages, and secondly, to study the efficiency of immunosuppressive therapy on the survival of these homografts.

Methods  Nonrelated mongrel dogs of both sexes were used, weighing 8.5 to 17 kg (19 to 38 lb). The anesthesia employed was pentobarbital sodium, supplemented with phencyclidine hydrochloride. Twenty-nine pancreatic homotransplantations were

First Page Preview View Large
First page PDF preview
First page PDF preview