The coexistence of surgical lesions of the parathyroid and thyroid glands appears sufficiently high to justify careful preoperative and operative evaluation of the other gland whenever surgery is required primarily for either of the two endocrine glands. In our experience with primary hyperparathyroidism, 40% of the patients have been found to have thyroid lesions of surgical significance. Since primary hyperparathyroidism is not a common disease, whereas nodular thyroid changes are frequent, the finding of a parathyroid tumor or hyperplasia at the time of thyroid surgery may be only an incidental finding. Nevertheless, this association occurs sufficiently frequently to justify surgical attention. Although the recognition of calcitonin suggests a greater physiologic connection between the parathyroid and thyroid glands than appreciated heretofore, the significance of this or other humoral agents in the functional relationship between these two endocrine glands in man has not been fully elucidated.
Thyroid Lesions in Primary Hyperparathyroidism
Laing VO, Frame B, Block MA. Associated Primary Hyperparathyroidism and Thyroid LesionsSurgical Considerations. Arch Surg. 1969;98(6):709-712. doi:10.1001/archsurg.1969.01340120057006