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July 1969

Gastric Secretion and Chronic Hyperparathyroidism

Author Affiliations

Galveston, Tex
From the departments of medicine and surgery, University of Texas Medical Branch, Galveston, Tex.

Arch Surg. 1969;99(1):9-14. doi:10.1001/archsurg.1969.01340130011003

Severe gastrointestinal symptoms arising in association with hyperparathyroidism are well known, but the pathophysiological characteristics of the symptoms are confusing. In some patients, these symptoms result from renal failure; in others, from acute or calcific pancreatitis, and in patients with acute hyperparathyroidism, inflammation and calcifications of the gastric mucosa occur. Furthermore, patients with hyperparathyroidism suffer from peptic ulcer, but the literature on the incidence of peptic ulcer in patients with this disorder is conflicting. Part of the confusion arises from the material available, the lack of reliable statistics on the frequency of ulcer disease in the general population, and the limitations imposed by diagnostic techniques.

Rogers1 who is generally cited as the first to report the concurrence of peptic ulcer and hyperparathyroidism, reported three such patients. Death resulted from uncontrolled hyperparathyroidism, but in two of the three patients the ulcers were healed at postmortem examination. Rogers' main concern was

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